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KMID : 0613820030130050604
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Journal of Life Science
2003 Volume.13 No. 5 p.604 ~ p.617
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Screening of anti-candidiosis agent from medicinal and wild plants
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Sohn Ho-Yong
Kum Eun-Joo
Kwon Yun-Suk
Kwon Gi-Seok
Jin Ingn-Yol
Kwon Ha-Young
Kwon Chong-Suk
Son Kun-Ho
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Abstract
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Candida albicans is one of the most common etiological agents in fungi-associated skin infections. There is an increase of candidiosis especially in the patient of acquired or induced immunodeficiency syndromes or in the event of long-term antibiotics and immuno-suppressor or cytotoxic therapies. To screen out reliable and effective anti-candidiosis agent, in this study, we have evaluated antifungal activity of 298 plant extracts against C. albicans. Based on the results of disc-paper method and determination of minimal inhibitory concentration, fifteen extracts were finally selected as possible sources of anti-candidiosis agent. Especially, six different plant extracts, such as Rubus parvifolius, Euphorbia pekinensis, Coptis chinensis, Eugenia aromaticum, Paeonia lactiflora var. hortensis and Paeonia suffruticosa showed strong antifungal activity against C. albicans, not to S. cerevisiae. These results suggested that medicinal and wild plants could be the potential source of antifungal agent.
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KEYWORD
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Antifungal activity, Candida albicans, Candidiosis, Medicinal and wild plants
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